CDE Detailed Report
Disease: cookie-policy
Sub-Domain: Safety Data
CRF:
Sub-Domain: Safety Data
CRF:
| CDE ID | CDE Name | Variable Name | Definition | Short Description | Additional Notes (Question Text) | Permissible Values | Description | Data Type | Disease Specific Instructions | Disease Specific Reference | Population | Classification (e.g., Core) | Version Number | Version Date | CRF Name (CRF Module / Guideline) | Sub Domain Name | Domain Name | Size | Input Restrictions | Min Value | Max Value | Measurement Type | Source | Form Set | Form | Field | Domain | CDASH Variable | CDASH Definition | CDASH Label | Controlled Terminology | Prompt | Essentiality | Question Text | CDASH imp guidance | SDTM IG target | csDSR | PhenX | Data Type | CRF Completion Inst | SDTMIG Target Var | SDTMIG Target Map | Codelist Name | PVs | Pre Pop Value | Query Display | List Style |
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| C60457 | Marrow hypoplasia megakaryotic text | MrwHypoplsiaMegakaryoticTxt | Text describing the megakaryotic component of bone marrow hypoplasia. | Text describing the megakaryotic component of bone marrow hypoplasia. | Megakaryotic | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 09:39:41.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities | 100 |
Free-Form Entry |
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| C60553 | Gene editing any associated cell clone minimum 20 percent clone population indicator | GnEdAnAsCeClMin20PctClPopInd | Indicator of whether any cell clone(s) associated with gene editing comprise >=20 percent of the population of clones. | Indicator of whether any cell clone(s) associated with gene editing comprise >=20 percent of the population of clones. | Do any cell clone/s associated with an editing event account for >=20% of all clones? | No;Yes | No;Yes | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 13:38:09.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Single Pre-Defined Value Selected |
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| C60489 | Burst forming unit erythroid cell positive for integrating viral vector percent value | BFUEPostvFrIntgrtVrlVctrPctVal | Value of the percentage of burst-forming unit - erythroid (BFU-E) cells positive for the integrating viral vector. | Value of the percentage of burst-forming unit - erythroid (BFU-E) cells positive for the integrating viral vector. | Percentage of Blood Cells Positive for Integrating Vector: BFU-E | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 13:33:03.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
0 | 100 | percent | ||||||||||||||||||||||||||||||
| C60521 | Gene editing conversion blood CD15 plus lineage percent value | GnEdConvBldCD15PlsLinePctVal | Value of the percentage of gene-editing conversions in the blood CD15+ lineage. | Value of the percentage of gene-editing conversions in the blood CD15+ lineage. | Percent conversion in Specific Blood Lineages: CD15+ | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 11:20:12.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
0 | 100 | percent | ||||||||||||||||||||||||||||||
| C60468 | Transfusion blood product type | TransfusionBloodProductTyp | Type(s) of blood product(s) introduced as part of transfusion. | Type(s) of blood product(s) introduced as part of transfusion. | Blood Product | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 10:29:39.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities | 100 |
Free-Form Entry |
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| C60564 | Malignancy new follow drug product infusion indicator | MlgnNwFlwDrgPrdInfsInd | Indicator of whether new malignancies were detected following infusion of drug product. | Indicator of whether new malignancies were detected following infusion of drug product. | Since drug product infusion has there been. New malignancy(ies)? | No;Yes | No;Yes | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 14:56:07.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Single Pre-Defined Value Selected |
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| C60500 | Evidence polyclonal gene-modified hematopoiesis specimen type | EvidPlyclnlGnModHmtpsSpecTyp | Type of specimen in which evidence was found of polyclonal gene-modified hematopoiesis. | Type of specimen in which evidence was found of polyclonal gene-modified hematopoiesis. | Specimen Type | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 14:23:03.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities | 25 |
Free-Form Entry |
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| C60532 | Gene editing on target indel bone marrow mononuclear cell count | GnEdOnTgtIndelBMMCCt | Count of on-target indels in gene editing of bone marrow mononuclear cells (BMMC). | Count of on-target indels in gene editing of bone marrow mononuclear cells (BMMC). | Bone Marrow: BMMC On-target Indels | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 11:40:19.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
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| C60543 | Gene editing off target site acceptable rate confirm indicator | GnEdOfTgtSitAcceptRtCnfrmInd | Indicator of whether an acceptable editing rate was confirmed for each off-target gene editing site. | Indicator of whether an acceptable editing rate was confirmed for each off-target gene editing site. | Acceptable editing rate confirmed for each off-target editing site: | No;Yes | No;Yes | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 12:08:45.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Single Pre-Defined Value Selected |
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| C60479 | Integrating viral vector for hematopoietic stem progenitor cell therapy promoter enhancer component text | IntViVeFHSPCTherProEnhCompTxt | Text field for describing the promoter and/or enhancer component(s) of the integrating viral vector(s) used for genetic manipulation of hematopoietic stem and progenitor cells. | Text field for describing the promoter and/or enhancer component(s) of the integrating viral vector(s) used for genetic manipulation of hematopoietic stem and progenitor cells. | Promoter/Enhancers in vector | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 13:06:17.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities | 50 |
Free-Form Entry |
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| C60511 | Cell clone proportional increase last two analysis identifier text | CelClnPrprtnIncrLst2AnlysIdTxt | Text field for identifying cell clone(s) that have increased as a proportion of the population of clones over the last two analyses. | Text field for identifying cell clone(s) that have increased as a proportion of the population of clones over the last two analyses. | Clone | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 16:51:48.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities | 25 |
Free-Form Entry |
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| C60447 | Hematology since previous report date status | HematolSncPrevRptDtStatus | Status of subject/participant's hematology since the date of the previous genotoxicity report. | Status of subject/participant's hematology since the date of the previous genotoxicity report. | Hematological Status since the date of last report: | Concerning;Non-concerning | Concerning;Non-concerning | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-21 16:43:01.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Single Pre-Defined Value Selected |
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| C60458 | Bone marrow myeloid erythroid cell ratio text | BonMrwMyldErythrdCelRatioTxt | Text field for capturing the ratio of maturing myeloid cells to erythroid cells in the bone marrow. | Text field for capturing the ratio of maturing myeloid cells to erythroid cells in the bone marrow. | What was M:E ratio: | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 09:44:38.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities | 10 |
Free-Form Entry |
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| C60554 | Gene editing off target cell clone minimum 20 percent clone population gene location | GnEdOfTgCeClMn20PcClPopGnLoc | Location of the gene containing, or nearest flanking gene to, the site of the off-target gene-editing clone that comprises >=20 percent of the population of all clones. | Location of the gene containing, or nearest flanking gene to, the site of the off-target gene-editing clone that comprises >=20 percent of the population of all clones. | List the site of off-target gene editing of dominant (=20% representation) clone(s) [e.g. gene location or flanking gene location], if known | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 13:41:43.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities | 25 |
Free-Form Entry |
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| C60490 | Integrating viral vector copy number bone marrow mononuclear cell value | IntgrtVrlVCNBMMCVal | Value of the integrating viral vector copy number (VCN) in bone marrow for bone marrow mononuclear cells (BMMC). | Value of the integrating viral vector copy number (VCN) in bone marrow for bone marrow mononuclear cells (BMMC). | Bone Marrow VCN: BMMC | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 13:25:18.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
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| C60522 | Gene editing conversion blood GPA plus lineage percent value | GnEdConvBldGPAPlsLinePctVal | Value of the percentage of gene-editing conversions in the blood GPA+ lineage. | Value of the percentage of gene-editing conversions in the blood GPA+ lineage. | Percent conversion in Specific Blood Lineages: GPA+ | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 11:20:12.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
0 | 100 | percent | ||||||||||||||||||||||||||||||
| C60469 | Transfusion frequency text | TransfusionFrequencyTxt | Text field for capturing frequency of blood transfusions | Text field for capturing frequency of blood transfusions | Transfusion frequency | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 10:31:04.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities | 50 |
Free-Form Entry |
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| C60565 | Malignancy new follow drug product infusion describe text | MlgnNwFlwDrgPrdInfsDscTxt | Text describing new malignancies detected following infusion of drug product. | Text describing new malignancies detected following infusion of drug product. | Since drug product infusion has there been. New malignancy(ies)? If yes, describe: | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 14:56:07.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities | 100 |
Free-Form Entry |
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| C60501 | Evidence polyclonal gene-modified hematopoiesis unique integrand count | EvPlyclnlGnMdHmtpsUniqIngrndCt | Count of unique integrands of the selected specimen type displaying evidence of gene-modified hematopoiesis. | Count of unique integrands of the selected specimen type displaying evidence of gene-modified hematopoiesis. | Number of unique integrands | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 14:24:48.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
0 | ||||||||||||||||||||||||||||||||
| C04807 | Vital status | VitStatus | Status of participant/subject as alive or dead | Status of participant/subject as alive or dead | Survival Status | Alive;Dead | Alive;Dead | Alphanumeric | Adult;Pediatric | Supplemental | 3.00 | 2013-07-20 10:21:25.65 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Single Pre-Defined Value Selected |
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| C60533 | Gene editing on target indel bone marrow CD34 plus cell count | GnEdOnTgtIndelBMCD34PlsCellCt | Count of on-target indels in gene editing of bone marrow CD34+ cells. | Count of on-target indels in gene editing of bone marrow CD34+ cells. | Bone Marrow: CD34+ On-target Indels | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 11:40:19.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
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| C60544 | Gene editing off target site dominant location | GnEdOffTgtSiteDominantLoc | Location(s) of the dominant off-target gene editing site(s). | Location(s) of the dominant off-target gene editing site(s). | What is the location of the dominant off-target site(s): | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 13:04:33.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities | 100 |
Free-Form Entry |
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| C60480 | Integrating viral vector copy number assessment type | IntgrtVrlVctrCpyNumAssessTyp | Type of assessment(s) of vector copy number (VCN) performed for the integrating viral vector products. | Type of assessment(s) of vector copy number (VCN) performed for the integrating viral vector products. | Vector Copy Number (VCN) performed in | Blood VCN;Bone marrow VCN;VCN in specific lineages;Percentage of Blood Cells Positive for Integrating Vector;Percentage of Bone Marrow Cells Positive for Integrating Vector | Blood vector copy number (VCN);Bone marrow vector copy number (VCN);Vector copy number (VCN) in specific lineages;Percentage of Blood Cells Positive for Integrating Vector;Percentage of Bone Marrow Cells Positive for Integrating Vector | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 13:12:48.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Multiple Pre-Defined Values Selected |
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| C60512 | Cell clone proportional increase last two analysis previous proportion percent value | ClClnPrpIncLst2AnlPrvPrpPctVal | Value as a percent of the proportion of all cell clones, that the specified cell clone showing proportional increase over the last two analyses presented during the previous analysis. | Value as a percent of the proportion of all cell clones, that the specified cell clone showing proportional increase over the last two analyses presented during the previous analysis. | Last % representation/abundance | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 16:53:58.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
0 | 100 | percent | ||||||||||||||||||||||||||||||
| C60448 | Bone marrow aspirate biopsy prior genetically modified hematopoietic stem cell infusion indicator | BoMwAspBpsPrGMHSCInfsInd | Indicator of whether bone marrow aspirate or biopsy was performed prior to infusion of genetically modified (GM) hematopoietic stem cells (HSC). | Indicator of whether bone marrow aspirate or biopsy was performed prior to infusion of genetically modified (GM) hematopoietic stem cells (HSC). | Was bone marrow aspirate/biopsy done prior to infusion? | No;Yes | No;Yes | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-21 16:53:07.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Single Pre-Defined Value Selected |
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| C60459 | Cytogenetic test indicator | CytogeneticTestInd | Indicator of whether cytogenetics was tested | Indicator of whether cytogenetics was tested | Was cytogenetics tested? | No;Yes | No;Yes | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 09:47:52.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Single Pre-Defined Value Selected |
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| C60555 | Gene editing off target cell clone minimum 20 percent clone population proportion value | GnEdOfTgCeClMn20PctClPoPrVal | Value, as a percentage, of the proportion of the population of clones that is comprised by off-target gene-editing clones with a proportion >= 20 percent. | Value, as a percentage, of the proportion of the population of clones that is comprised by off-target gene-editing clones with a proportion >= 20 percent. | Percent Representation/Relative Abundance | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 13:45:16.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
20 | 100 | percent | ||||||||||||||||||||||||||||||
| C60491 | Integrating viral vector copy number bone marrow CD34 plus lineage value | IntgrtVrlVCNCD34PlsLneagVal | Value of the integrating viral vector copy number (VCN) in bone marrow for the CD34+ lineage. | Value of the integrating viral vector copy number (VCN) in bone marrow for the CD34+ lineage. | Bone Marrow VCN: CD34+ | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 13:25:18.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
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| C60523 | Gene editing conversion blood CD14 plus lineage percent value | GnEdConvBldCD14PlsLinePctVal | Value of the percentage of gene-editing conversions in the blood CD14+ lineage. | Value of the percentage of gene-editing conversions in the blood CD14+ lineage. | Percent conversion in Specific Blood Lineages: CD14+ | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 11:20:12.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
0 | 100 | percent | ||||||||||||||||||||||||||||||
| C60470 | Hematological toxicity probable cause analysis perform indicator | HematToxProbCausAnlPrfmInd | Indicator of whether an analysis has been performed to identify the probable cause of hematological toxicity. | Indicator of whether an analysis has been performed to identify the probable cause of hematological toxicity. | Has analysis been performed to determine probable cause of hematological toxicity? | No;Yes | No;Yes | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 10:33:16.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Single Pre-Defined Value Selected |
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| C60566 | Neurologic disorder preexist new incidence exacerbation follow drug product infusion indicator | NrDsPrxNwInExFlwDrPrInfInd | Indicator of whether a pre-existing neurological disorder presented exacerbation or a new incidence following drug product infusion. | Indicator of whether a pre-existing neurological disorder presented exacerbation or a new incidence following drug product infusion. | Since drug product infusion has there been new incidence or exacerbation of a pre-existing neurologic disorder? | No;Yes | No;Yes | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 15:02:28.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Single Pre-Defined Value Selected |
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| C60502 | Polyclonal gene-modified hematopoiesis over 999 unique integration indicator | PlyclnGnMdHmtpsOv999UnqIntgInd | Indicator of whether >=1000 unique integrations providing evidence of polyclonal gene-modified hematopoiesis were identified in the selected specimen type. | Indicator of whether >=1000 unique integrations providing evidence of polyclonal gene-modified hematopoiesis were identified in the selected specimen type. | "Rich" (polyclonal population with >=1000 unique integrations) | No;Yes | No;Yes | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 14:27:42.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Single Pre-Defined Value Selected |
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| C14052 | Hemoglobin measurement | HemoglobMeasr | The measurement for hemoglobin. | The measurement for hemoglobin. | The latest Complete Blood Count Hb | Numeric Values | Adult;Pediatric | Supplemental | 3.00 | 2013-06-21 00:00:00.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
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| C60534 | Gene editing on target indel bone marrow colony forming cell count | GnEdOnTgtIndelBMCFCCt | Count of on-target indels in gene editing of bone marrow colony forming cells (CFC). | Count of on-target indels in gene editing of bone marrow colony forming cells (CFC). | Bone Marrow: CFC On-target Indels | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 11:40:19.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
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| C60545 | Gene editing off target site dominant location type | GnEdOffTgtSiteDomLocTyp | Type of location of dominant off-target gene editing site | Type of location of dominant off-target gene editing site | Is the editing site location: | Inter-genic;Intra-genic | Inter-genic;Intra-genic | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 13:06:18.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Single Pre-Defined Value Selected |
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| C60481 | Vector copy number blood value | VectrCopyNumBloodVal | Value of the vector copy number (VCN) for blood. | Value of the vector copy number (VCN) for blood. | Blood VCN | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 13:20:21.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
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| C60513 | Cell clone proportional increase last two analysis current proportion percent value | ClClnPrpIncLst2AnlCurPrpPctVal | Value as a percent of the proportion of all cell clones, that the specified cell clone showing proportional increase over the last two analyses presented during the current (i.e., most recent) analysis. | Value as a percent of the proportion of all cell clones, that the specified cell clone showing proportional increase over the last two analyses presented during the current (i.e., most recent) analysis. | Current % Abundance | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 16:53:58.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
0 | 100 | percent | ||||||||||||||||||||||||||||||
| C60449 | Bone marrow aspirate biopsy prior genetically modified hematopoietic stem cell infusion date | BoMwAspBpsPrGMHSCInfsDate | Indicator of whether bone marrow aspirate or biopsy was performed prior to infusion of genetically modified (GM) hematopoietic stem cells (HSC). | Indicator of whether bone marrow aspirate or biopsy was performed prior to infusion of genetically modified (GM) hematopoietic stem cells (HSC). | Was bone marrow aspirate/biopsy done prior to infusion? Date | Date or Date & Time | Adult;Pediatric | Supplemental | 1.00 | 2021-04-21 16:53:07.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
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| C60460 | Cytogenetic abnormality indicator | CytogeneticAbnormalityInd | Indicator of whether abnormalities were identified in cytogenetics testing. | Indicator of whether abnormalities were identified in cytogenetics testing. | Abnormalities | No;Yes | No;Yes | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 09:49:40.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Single Pre-Defined Value Selected |
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| C60556 | Gene editing off-site target clone minimum 20 percent representation genetic location | GnEdOfStTgClMn20PctRpGntcLoc | Location, relative to other genes on a DNA strand, of any clone(s) having >=20 percent representation within the population of clones. | Location, relative to other genes on a DNA strand, of any clone(s) having >=20 percent representation within the population of clones. | Is the location of the dominant gene editing site | Within or <50Kb of a known oncogene;Within or <50Kb of a Transcriptional Unit of any gene;Within or <50Kb of Cell signaling/proliferation Gene | Within, or fewer than 50 kilobases away from, of a known oncogene;Within, or fewer than 50 kilobases away from, a Transcriptional Unit of any gene;Within, or fewer than 50 kilobases away from, a Cell signaling/proliferation Gene | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 13:53:51.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Multiple Pre-Defined Values Selected |
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| C60492 | Integrating viral vector copy number bone marrow colony forming cell value | IntgrtVrlVCNBonMarowCFCVal | Value of the integrating viral vector copy number (VCN) in bone marrow for colony forming cells (CFC). | Value of the integrating viral vector copy number (VCN) in bone marrow for colony forming cells (CFC). | Bone Marrow VCN: CFC | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 13:25:18.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
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| C60524 | Gene editing blood CD3 plus lineage on target indel count | GnEdBldCD3PlsLinOnTgtIndelCt | Count of gene-editing on-target indels in the blood CD3+ lineage. | Count of gene-editing on-target indels in the blood CD3+ lineage. | On-target Indels in Specific Blood Lineages: CD3+ | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 11:20:12.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
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| C60471 | Abnormal hematopoeisis related to caused by genetic manipulation indicator | AbHmtpsRltToCsByGenManipInd | Indicator of whether abnormal hematopoeisis is related to or probably caused by genetic manipulation | Indicator of whether abnormal hematopoeisis is related to or probably caused by genetic manipulation | Is it related or likely due to the genetic manipulation? | No;Yes | No;Yes | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 11:47:42.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Single Pre-Defined Value Selected |
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| C60567 | Neurologic disorder preexist new incidence exacerbation follow drug product infusion describe text | NrDsPrxNwInExFlwDrPrInfDscTxt | Text describing exacerbation or new incidence of a pre-existing neurological disorder following drug product infusion. | Text describing exacerbation or new incidence of a pre-existing neurological disorder following drug product infusion. | Since drug product infusion has there been new incidence or exacerbation of a pre-existing neurologic disorder? If yes, describe: | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 15:02:28.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities | 255 |
Free-Form Entry |
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| C60503 | Vector copy number specimen type evidence gene modified hematopoiesis value | VCNSpcmnTypGnModHmtpsVal | Value of the vector copy number (VCN) for the selected specimen type displaying evidence of polyclonal gene-modified hematopoiesis | Value of the vector copy number (VCN) for the selected specimen type displaying evidence of polyclonal gene-modified hematopoiesis | VCN | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 14:32:32.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
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| C57964 | Laboratory procedure percent neutrophils value | LabProcedurePrctNeutrophilsVal | Value of percent neutrophils. | Value of percent neutrophils. | The latest Complete Blood Count Neutrophils % | Numeric Values | Adult;Pediatric | Supplemental | 1.00 | 2018-01-22 11:03:02.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Free-Form Entry |
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| C60535 | Gene editing off target interrogation bioinformatic type | GnEdOffTgtInterrgntBioinfoTyp | Type of bioinformatic method employed in interrogating off-target gene-editing results. | Type of bioinformatic method employed in interrogating off-target gene-editing results. | Off Target Interrogation: Bioinformatic | CRISPOR;CRISTA;Other (list) | CRISPOR;CRISTA;Other (list) | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 11:50:01.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Multiple Pre-Defined Values Selected |
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| C60546 | Gene editing site translocation on off target cytogenetic detection indicator | GnEdStTrnslocOnOfTgtCytoDetINd | Indicator of whether gene editing translocations between on-target and off-target sites were detected by cytogenetics. | Indicator of whether gene editing translocations between on-target and off-target sites were detected by cytogenetics. | Translocations between on-target and off-target editing sites detected by: Cytogenetics | No;Yes | No;Yes | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 13:10:07.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Single Pre-Defined Value Selected |
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| C60482 | Integrating viral vector blood CD3 depleted indicator | IntgrtVrlVctrBldCD3DpltInd | Indicator of whether the integrating viral vector copy number (VCN) of blood is depleted of CD3. | Indicator of whether the integrating viral vector copy number (VCN) of blood is depleted of CD3. | CD3 depleted? | No;Yes | No;Yes | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-22 13:21:58.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Single Pre-Defined Value Selected |
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| C60514 | Gene modified hematopoiesis best characterize type | GenModHemtopoisBstCharTyp | Type of condition that best characterizes the observed gene-modified hematopoiesis. | Type of condition that best characterizes the observed gene-modified hematopoiesis. | Based on VCN and VISA, what best describes the gene-modified hematopoiesis? | Clonal dominance;Oligoclonal hematopoiesis;MDS;Leukemia/lymphoma | Clonal dominance;Oligoclonal hematopoiesis;Myelodysplastic syndrome (MDS);Leukemia/lymphoma | Alphanumeric | Adult;Pediatric | Supplemental | 1.00 | 2021-04-23 10:54:46.0 | Genotoxicity | Safety Data | Adverse Events/Toxicities |
Single Pre-Defined Value Selected |