Dr. Courtney Fitzhugh, M.D.

The vision of the Cure Sickle Cell Initiative is to accelerate the development of treatments aimed at genetic cures for sickle cell disease.

To this end, the Initiative intends to assist investigators as they move meritorious, peer-reviewed projects through Investigational New Drug (IND) enabling studies and into clinical trials. The Initiative also intends to fund projects that support the clinical evaluation of novel genetic therapy and gene editing. The Cure Sickle Cell Initiative does not replace NHLBI funding of sickle cell disease-focused science through traditional mechanisms. NHLBI continues to fund those investigator-initiated research on sickle cell disease.


No active funding announcements at this time.


The NHLBI is soliciting applications for preclinical and clinical projects focused on curative strategies for sickle cell disease in the areas of gene therapy (replacement) and gene editing. Proposed projects may also be focused on developing or refining activities that improve the safety or efficacy of the clinical protocol for gene therapy or gene edited autologous hematopoietic transplantation (e.g. improved bone marrow conditioning regimens, maximizing stem cell mobilization and harvesting).